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Cellular and molecular mechanisms of sulfur mustard toxicity on spermatozoa and male fertility

Abstract

Sulfur mustard (SM) is a toxic compound that can target human spermatozoa. It induces a wide variety of pathologic effects in human reproductive organ, including disturbance in sexual hormones, testicular atrophy, impaired spermatogenesis, poor quality of sperm, defetcs in embryo development, childhood physical abnormalities, and severe fertility problems. However, molecular and cellular mechanisms of SM action on male reproductive health and human sperm function are not clear. Excessive production of reactive oxygen species (ROS) and resulted oxidative stress (OS) is likely a significant mechanism of SM action which can be associated with sperm DNA damage, membrane lipid peroxidation, reduced membrane fluidity, mitochondrial deficiency, apoptosis, and poor sperm quality. In this review, we aim to discuss cellular and molecular mechanisms of SM action on sperm and reproductive health, the significance of OS and mechanisms by which SM enhances infertility rate among SM-exposed individuals.

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Publication details

The article was received on 23 Feb 2018, accepted on 09 Jul 2018 and first published on 09 Jul 2018


Article type: Review Article
DOI: 10.1039/C8TX00062J
Citation: Toxicol. Res., 2018, Accepted Manuscript
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    Cellular and molecular mechanisms of sulfur mustard toxicity on spermatozoa and male fertility

    A. Beigi Harchegani, M. Mirnam Niha, M. Sohrabiyan, M. Ghatresamani, E. Tahmasbpour Marzony and A. Shahriary, Toxicol. Res., 2018, Accepted Manuscript , DOI: 10.1039/C8TX00062J

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