Jump to main content
Jump to site search


Urinary metabolomics reveals novel interactions between metals exposure and amino acid metabolic stress during pregnancy

Abstract

Pregnant women are a special group of people who are undergoing profound structural modifications in the uterus, breast, adipose tissue and extracellular fluids. Amino acid metabolic stress is a special physical process that occurs during pregnancy. Metals constitute a fundamental part of the maternal body and have a universal effect on amino acid metabolism. However, the exact interaction between metals and amino acid metabolism during pregnancy is unknown. The aims of the present study were to determine the correlations of metals with amino acid metabolic intermediates in the urine of 232 healthy pregnant women in their first, second and third trimesters during normal pregnancy. Sixteen metals in the urine of 232 healthy pregnant women in their first, second and third trimesters were quantified using inductively coupled plasma mass spectrometry (ICP-MS). An ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometer (UPLC-QTOFMS)-based metabolomics approach was conducted to detect the intermediate products involved in amino acid metabolism during the whole pregnancy. A panel regression model was established to investigate the relationship between urine metals and amino acid metabolism. Seven metals—cadmium, cobalt, copper, cesium, manganese, thallium and vanadium—showed significant associations with amino acid metabolic intermediates, including 2-oxoarginine, 3-indoleacetonitrile, indole, indole-5,6-quinone, N2-succinyl-l-glutamic acid 5-semialdehyde, N-methyltryptamine and N-succinyl-l,l-2,6-diaminopimelate, in the healthy pregnant cohort. These findings indicated that exposure to cadmium, cobalt, copper, cesium, manganese, thallium and vanadium significantly affected the metabolic status of tryptophan, arginine, proline, tyrosine and lysine metabolism in the maternal body during normal pregnancy.

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jan 2018, accepted on 20 Jul 2018 and first published on 24 Jul 2018


Article type: Paper
DOI: 10.1039/C8TX00042E
Citation: Toxicol. Res., 2018, Accepted Manuscript
  •   Request permissions

    Urinary metabolomics reveals novel interactions between metals exposure and amino acid metabolic stress during pregnancy

    M. Wang, W. Xia, H. Liu, F. Liu, H. Li, H. Chang, J. Sun, W. Liu, X. Sun, Y. Jiang, H. Liu, C. Wu, X. Pan, Y. Li, W. Rang, S. Lu and S. Xu, Toxicol. Res., 2018, Accepted Manuscript , DOI: 10.1039/C8TX00042E

Search articles by author

Spotlight

Advertisements