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3D graphene/hydroxypropyl-β-cyclodextrin nanocomposite as an electrochemical chiral sensor for the recognition of tryptophan enantiomers

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Abstract

A novel and facile chiral sensing platform has been designed for electrochemical enantiomer recognition based on the coupling of three-dimensional-graphene with hydroxypropyl-β-cyclodextrin (3D-G/HP-β-CD). The chiral platform synergistically exploits HP-β-CD as a supramolecular chiral recognizer and 3D-G as an electrochemical indicator, to recognize tryptophan (Trp) enantiomers by differential pulse voltammetry (DPV) approach with significantly discernable electrochemical signals. The different host–guest interactions of D- and L-Trp with HP-β-CD reveal high binding affinity to target L-tryptophan for sensing tryptophan isomers. Moreover, we found that the peak currents of the two enantiomers showed a linear response in the concentration range of 0.5–175 μM with low detection limits of 9.6 nM and 38 nM for L- and D-Trp (S/N = 3), respectively, exhibiting remarkable sensitivity, fine reproducibility as well as great stability. This process, which is the initial demonstration of cyclodextrin-functionalized 3D-G for an electrochemical chiral recognition application, provides a new strategy for enantiosensing.

Graphical abstract: 3D graphene/hydroxypropyl-β-cyclodextrin nanocomposite as an electrochemical chiral sensor for the recognition of tryptophan enantiomers

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Publication details

The article was received on 04 Sep 2018, accepted on 18 Oct 2018 and first published on 19 Oct 2018


Article type: Paper
DOI: 10.1039/C8TC04448A
Citation: J. Mater. Chem. C, 2018, Advance Article
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    3D graphene/hydroxypropyl-β-cyclodextrin nanocomposite as an electrochemical chiral sensor for the recognition of tryptophan enantiomers

    W. Liang, Y. Rong, L. Fan, W. Dong, Q. Dong, C. Yang, Z. Zhong, C. Dong, S. Shuang and W. Wong, J. Mater. Chem. C, 2018, Advance Article , DOI: 10.1039/C8TC04448A

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