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Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

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Abstract

Herein, we report novel hyaluronic acid formulated nanoparticles containing a platinum(II) conjugated silicon(IV) phthalocyanine (SiPc–Pt–HA) for tumor targeted red light photodynamic therapy and chemotherapy. The SiPc–Pt–HA conjugate showed specific uptake, photo-enhanced cytotoxicity (∼1500 fold) and mitochondrial accumulation in breast cancer over normal cells.

Graphical abstract: Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

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Publication details

The article was received on 26 Sep 2018, accepted on 15 Oct 2018 and first published on 24 Oct 2018


Article type: Communication
DOI: 10.1039/C8TB02533A
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

    K. Mitra, M. Samsó, C. E. Lyons and M. C. T. Hartman, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB02533A

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