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Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(I) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

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Abstract

We have investigated core-crosslinked star polymer nanoparticles designed with tunable release chemistries as potential nanocarriers for a photoactive Re(I) organometallic complex. The nanoparticles consisted of a brush poly(oligo-ethylene glycol)methyl ether acrylate (POEGA) corona and a cross-linked core of non-biodegradable N,N′-methylenebis(acrylamide) (MBAA) and either pentafluorophenyl acrylate (PFPA), 3-vinyl benzaldehyde (VBA) or diacetone acrylamide (DAAM). Each star was modified with an amine functionalized photodynamic agent (i.e. a rhenium(I) organometallic complex) resulting in the formation of either a stable amide bond (POEGA-star-PFPA), or hydrolytically labile aldimine (POEGA-star-VBA) or ketimine bonds (POEGA-star-DAAM). These materials revealed linker dependent photo- and cytotoxicity when tested in vitro against non-cancerous lung fibroblast MRC-5 cells and HeLa human cervical cancer cells: the toxicity results correlated with final intracellular Re concentrations.

Graphical abstract: Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

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Publication details

The article was received on 19 Sep 2018, accepted on 28 Oct 2018 and first published on 29 Oct 2018


Article type: Communication
DOI: 10.1039/C8TB02464B
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(I) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

    S. H. Yu, M. Patra, S. Ferrari, P. Ramirez Garcia, N. A. Veldhuis, L. M. Kaminskas, B. Graham, J. F. Quinn, M. R. Whittaker, G. Gasser and T. P. Davis, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB02464B

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