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NIR-Absorbing Water-Soluble Conjugated Polymer Dots for Photoacoustic Imaging-Guided Photothermal/Photodynamic Synergetic Cancer Therapy

Abstract

“Theranostics” becomes increasingly significant in today’s personalized precision medicine. Here, we developed a new NIR-absorbing photo-theranostic agent based on water-soluble diketopyrrolopyrrole (DPP) conjugated polymer (WSCP) dots. The WSCPs can be easily self-assembled into WSCP dots under ultrasonication only, instead of any other nano-technology. Compared to the monomers of WSCPs, no fluorescence emission but photoacoustic (PA) signal can be detected from WSCP dots upon laser irradiation due to the reduced energy loss from excited state. PA imaging in vivo indicated that WSCP dots can accumulate at tumor site after 4 h post-injection. More importantly, WSCP dots can not only generate heat with a photothermal conversion efficiency of ~54%, but also produce reactive oxygen species (ROS, QY ≈ 13%). Furthermore, in vitro and in vivo experiments confirmed that WSCP dots can effectively inhibit the tumor growth by synergetic photothermal/photodynamic therapy. All these results indicate the great potential of WSCP dots as highly efficient theranostic agents in PA imaging-guided synergetic cancer treatment.

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Publication details

The article was received on 06 Sep 2018, accepted on 03 Oct 2018 and first published on 03 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB02349B
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    NIR-Absorbing Water-Soluble Conjugated Polymer Dots for Photoacoustic Imaging-Guided Photothermal/Photodynamic Synergetic Cancer Therapy

    X. Dong, H. Shi, Y. Wang, X. Huang, P. Liang, Y. Tang, Y. Zhang, N. Fu and W. Huang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02349B

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