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A single fluorescent probe for imaging ribonucleic acid and sulfur dioxide in living systems and unique application in tumor and normal animals

Abstract

To investigate the unique interrelation of ribonucleic acid (RNA) and sulfur dioxide (SO2) in living systems, it is necessary to construct novel molecular tools that could detect RNA and SO2 in living cancer cells and animals. Herein, we have constructed a unique fluorescent probe EPI-RS for imaging RNA and SO2 with distinct fluorescence signals in living systems. This type of probe shows a series of advantages, such as high photostability, large Stokes shift, high selectivity and sensitivity in pure water system. View of the above advantages, the probe EPI-RS could image RNA and SO2 by “turn on” and “turn off” fluorescence signals in the living cells, tissues, zebrafish and mice; Moreover, the probe EPI-RS could sense SO2 in the living cells, tissues, zebrafish and mice. Interestingly, the probe EPI-RS exhibits different in vivo imaging properties in normal and tumor animals; Furthermore, it is firstly found that the probe EPI-RS could detect SO2 in normal mice.

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Publication details

The article was received on 15 Aug 2018, accepted on 07 Sep 2018 and first published on 11 Sep 2018


Article type: Paper
DOI: 10.1039/C8TB02144A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    A single fluorescent probe for imaging ribonucleic acid and sulfur dioxide in living systems and unique application in tumor and normal animals

    W. Wang, Y. Liu, J. Niu and W. Lin, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02144A

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