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Preparation and characterization of layer-by-layer hypoglycemic nanoparticles with pH-sensitivity for oral insulin delivery

Abstract

The new self-assembled layer-by-layer nanoparticles based on hypoglycemic, mucoadhesive, epithelium penetration and pH-sensitive functional materials has been synthesized. The confirmed hypoglycemic and negatively charged polygalacturonic acid, the well know cell penetrator and positively charged chitosan, and the pH-sensitive polymer and negatively charged alginate have been applied in this nanoparticle. The electrical attraction between negatively charged PGLA and alginate and positively charged chitosan motivated assemblage and supported the pH-sensitivity of this nanoparticles. The LBL4 and LBL4-Alg nanoparticles were characterized in vitro and in vivo. The pH-sensitivity of LBL4-Alg nanoparticles were much clearer with the turning point near pH = 5. Moreover, according to the pharmacological and pharmacokinetic studies, the significant hypoglycemic effect could be revealed only 1 h after gavage of LBL4 and LBL4-Alg nanoparticles. Insulin continually released at least for 6 h. These results show that the new self-assembled LBL4-Alg nanoparticles with pH-sensitivity showed great potential for insulin oral delivery.

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Publication details

The article was received on 11 Aug 2018, accepted on 06 Oct 2018 and first published on 08 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB02113A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Preparation and characterization of layer-by-layer hypoglycemic nanoparticles with pH-sensitivity for oral insulin delivery

    L. Zhang, H. Qin, J. Li, J. Qiu, J. Huang, M. Li and Y. Guan, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02113A

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