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Multifunctional hyaluronic acid-derived carbon dots for self-targeted imaging- guided photodynamic therapy

Abstract

It is of vital importance to engineer the surface structures of carbon dots (CDs) to satisfy their practical biomedical applications, including imaging and treatment. In this work, one kind of hyaluronic acid derived CDs (HA-CDs) were synthesized via a facile one-step hydrothermal method using cancer cell-targeted HA as precursor. The as-prepared HA-CDs were actively targeted toward CD44 receptor-overexpressed cancer cells because partial HA structure remained on the surface of HA-CDs. Beyond that, HA-CDs can act as a novel photosensitizer, because it can effectively generate O2• under 650-nm laser irradiation, and also has an excellent blue photoluminorescent emission. The in vitro results revealed that HA-CDs selectively imaged CD44-overexpressing cancer cells and inhibited their growth under 650-nm laser irradiation. Thus, HA-CDs can serve as a promising self-targeted imaging-guided photodynamic therapy (PDT) agent for cancer. The present research provides a promising new method to simply construct multifunctional CD-based targeted phototheranostic systems.

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Publication details

The article was received on 28 Jul 2018, accepted on 04 Sep 2018 and first published on 05 Sep 2018


Article type: Paper
DOI: 10.1039/C8TB01957F
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Multifunctional hyaluronic acid-derived carbon dots for self-targeted imaging- guided photodynamic therapy

    L. Zhang, Z. Lin, Y. Yu, B. Jiang and X. Shen, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01957F

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