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Surface engineering of titanium implants with enzyme-triggered antibacterial properties and enhanced osseointegration in vivo

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Abstract

Preventing bacterial infection and improving the osseointegration of titanium (Ti) and its alloys are both highly crucial factors for their long-term successful implantation in clinical applications. However, the straightforward applications of antibacterial surfaces on Ti-based materials remain limited due to their side effects on cytocompatibility. Herein, catechol-functionalized multilayer films composed of dopamine-modified hyaluronic acid (HA-c) and 3,4-dihydroxyhydrocinnamic acid-modified chitosan (Chi-c) were developed on Ti substrates modified with TiO2 nanotube arrays loaded with an antibacterial drug. The treated Ti substrate showed strong hydrophilicity, with a water contact angle of about 20°, and obviously inhibited early-stage bacterial adhesion. Moreover, this system displayed an enzyme-responsive release of antibacterial drug triggered by the hyaluronidase degradation of HA-c, which exhibited effective antibacterial ability and eliminated side effects caused by burst release of antibiotics. Meanwhile, the modified Ti substrates significantly promoted initial osteoblast adhesion through up-regulating the expression of adhesion-related genes, including integrin αv and β3. More importantly, this prepared coating with bacterial self-responsiveness improved osseointegration and prevented bacterial infection of Ti implants in vivo. Overall, our developed catechol-functionalized and bacterial self-responsive coating on Ti substrate has great significance in clinical applications of orthopedic and dental implants.

Graphical abstract: Surface engineering of titanium implants with enzyme-triggered antibacterial properties and enhanced osseointegration in vivo

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Publication details

The article was received on 25 Jul 2018, accepted on 04 Nov 2018 and first published on 06 Nov 2018


Article type: Paper
DOI: 10.1039/C8TB01918E
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Surface engineering of titanium implants with enzyme-triggered antibacterial properties and enhanced osseointegration in vivo

    Z. Yuan, S. Huang, S. Lan, H. Xiong, B. Tao, Y. Ding, Y. Liu, P. Liu and K. Cai, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB01918E

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