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Issue 35, 2018

Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications

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Abstract

Unimolecular micelles, as a class of single-molecular micelles, are structurally stable regardless of their concentrations or alterations of the outer environment such as pH, temperature, ion strength etc. in comparison with conventional polymeric micelles. Polyester unimolecular micelles are extensively applied in bio-medical fields because of their stability, biocompatibility, biodegradability, structural-controllabilty etc. In this review, the most recent developments in polyester unimolecular micelle designs in terms of Boltorn polymer H40 core, cyclodextrin, dendrimer or dendrimer-like polymer, or polyhedral oligomeric silsesquioxane (POSS) based polyester unimolecular micelles are presented. The significance and application in biomedical fields including drug delivery, bio-imaging and theranostics are also classified in this review. Finally, the remaining challenges and future perspectives for further development of unimolecular micelles as therapeutic materials are also discussed.

Graphical abstract: Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications

Article information


Submitted
20 Jul 2018
Accepted
14 Aug 2018
First published
15 Aug 2018

J. Mater. Chem. B, 2018,6, 5488-5498
Article type
Review Article

Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications

X. Liu, X. Fan, L. Jiang, X. J. Loh, Y. Wu and Z. Li, J. Mater. Chem. B, 2018, 6, 5488 DOI: 10.1039/C8TB01883A

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