Jump to main content
Jump to site search


NIR Organic Dyes based on Phenazine-cyanine for Photoacoustic Imaging-guided Photothermal Therapy

Abstract

As the non-invasive diagnosis and therapy methods, photoacoustic (PA) imaging and photothermal therapy (PTT) have attracted extensive attention. Herein, two new acceptor-donor-acceptor near infrared organic phenazine-cyanine dyes PH-1 and PH-2 were reported for photoacoustic imaging guided photodynamic therapy. In the strong donor phenazine molecule, the electron-withdrawing indole salt unit is introduced for the absorption to near-infrared region. In order to improve water solubility, two organic dyes were assembled with human serum albumin (HSA) to form nanoparticles at appropriate size PH-1@HSA and PH-2@HSA, which showed excellent stability both in weak acid and alkalescent environment. Moreover, the results showed that PH-1@HSA and PH-2@HSA nanoparticles can transform luminous energy to thermal energy in vitro and vivo effectively, and can be utilized for PA imaging. Importantly, PH-1@HSA can gather in mice subcutaneous tumor by enhanced permeability and retention (EPR) and hurt cancer tissue effectively.

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Jul 2018, accepted on 04 Oct 2018 and first published on 08 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB01750F
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
  •   Request permissions

    NIR Organic Dyes based on Phenazine-cyanine for Photoacoustic Imaging-guided Photothermal Therapy

    J. Hua, Y. Yan, J. Chen, Z. Yang, X. Zhang and Z. Liu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01750F

Search articles by author

Spotlight

Advertisements