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Issue 45, 2018
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NIR organic dyes based on phenazine-cyanine for photoacoustic imaging-guided photothermal therapy

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Abstract

As non-invasive diagnosis and therapy methods, photoacoustic (PA) imaging and photothermal therapy (PTT) have attracted extensive attention. Herein, two new acceptor–donor–acceptor near-infrared organic phenazine-cyanine dyes PH-1 and PH-2 were reported for photoacoustic imaging-guided photodynamic therapy. In the strong donor phenazine molecule, the electron-withdrawing indole salt unit was introduced for absorption to the near-infrared region. To improve water solubility, the two organic dyes were assembled with human serum albumin (HSA) to form nanoparticles of appropriate sizes, i.e., PH-1@HSA and PH-2@HSA, which showed excellent stability in both weakly acidic and weakly basic environments. Moreover, the results showed that PH-1@HSA and PH-2@HSA nanoparticles can effectively transform luminous energy to thermal energy in vitro and in vivo, and they can be utilized for PA imaging. Importantly, PH-1@HSA can accumulate in mice subcutaneous tumors by enhanced permeability and retention (EPR) and damage cancer tissues effectively.

Graphical abstract: NIR organic dyes based on phenazine-cyanine for photoacoustic imaging-guided photothermal therapy

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Publication details

The article was received on 04 Jul 2018, accepted on 04 Oct 2018 and first published on 08 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB01750F
Citation: J. Mater. Chem. B, 2018,6, 7420-7426
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    NIR organic dyes based on phenazine-cyanine for photoacoustic imaging-guided photothermal therapy

    Y. Yan, J. Chen, Z. Yang, X. Zhang, Z. Liu and J. Hua, J. Mater. Chem. B, 2018, 6, 7420
    DOI: 10.1039/C8TB01750F

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