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Issue 33, 2018
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Integration of organic electrochemical transistors and immuno-affinity membranes for label-free detection of interleukin-6 in the physiological concentration range through antibody–antigen recognition

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Abstract

We demonstrate the label-free and selective detection of interleukin-6 (IL-6), a key cell-signaling molecule in biology and medicine, by integrating an OECT with an immuno-affinity regenerated cellulose membrane. The objective of the membrane is to increase the local concentration of IL-6 at the sensing electrode and, thereby, enhance the device response for concentrations falling within the physiological concentration range of cytokines. The OECT gate electrode is functionalized with an oligo(ethylene glycol)-terminated self-assembled alkanethiolate monolayer (SAM) for both the immobilization of anti IL-6 antibodies and the inhibition of non-specific biomolecule binding. The OECT gate/electrolyte interface is exploited for the selective detection of IL-6 through the monitoring of antigen–antibody binding events occurring at the gate electrode.

Graphical abstract: Integration of organic electrochemical transistors and immuno-affinity membranes for label-free detection of interleukin-6 in the physiological concentration range through antibody–antigen recognition

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Publication details

The article was received on 28 Jun 2018, accepted on 30 Jul 2018 and first published on 30 Jul 2018


Article type: Paper
DOI: 10.1039/C8TB01697F
Citation: J. Mater. Chem. B, 2018,6, 5400-5406
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    Integration of organic electrochemical transistors and immuno-affinity membranes for label-free detection of interleukin-6 in the physiological concentration range through antibody–antigen recognition

    D. Gentili, P. D’Angelo, F. Militano, R. Mazzei, T. Poerio, M. Brucale, G. Tarabella, S. Bonetti, S. L. Marasso, M. Cocuzza, L. Giorno, S. Iannotta and M. Cavallini, J. Mater. Chem. B, 2018, 6, 5400
    DOI: 10.1039/C8TB01697F

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