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Resilient and flexible chitosan/silk cryogel incorporated with Ag/Sr co-doped nanoscale hydroxyapatite for osteoinductivity and antibacterial properties

Abstract

Cryogels from natural biopolymers, especially chitosan (CS) and silk fibroin (SF), have attracted significant attention for bone tissue engineering due to their good biocompatibility and tissue affinity. However, they are still not widely applied in clinics because of their poor mechanical properties, and lack of osteoinductivity and antibacterial properties. Here, integrating a physio-chemical hybrid-crosslinking strategy and the freeze-drying method, the authors have prepared a resilient and flexible chitosan/silk cryogel with Ag and Sr co-doped hydroxyapatite (AgSrHA). The cryogel exhibits super resilience and flexibility, which guarantees the mechanical strength required for bone repair. Furthermore, the cryogel possesses long-term effective antibacterial and osteoinductivity due to the slow release of Ag and Sr ions. The physio-chemical hybrid-crosslinking points were introduced into CS/SF network by treated with a mixture of alkaline and polyethylene glycol glycidyl ether (PEGDE) at 60 °C, and which endowed the cryogel with super resilience and flexibility. Nanoscale AgSrHA was incorporated into the CS/SF network to further enhance the mechanical properties of the cryogel. In addition, Ag and Sr were doped into the HA crystal lattice, which not only prevents cytotoxicity by avoiding the ion burst release behavior, but which also can achieve antibacterial and osteoinductive properties for a long period of time. In short, the AgSrHA/CS/SF cryogel with excellent mechanical property and long-term effective dual-biofunction of antibacterial properties and osteoinductivity, would be an ideal candidate for successful bone repair in clinics.

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Publication details

The article was received on 26 Jun 2018, accepted on 03 Oct 2018 and first published on 05 Oct 2018


Article type: Paper
DOI: 10.1039/C8TB01672K
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Resilient and flexible chitosan/silk cryogel incorporated with Ag/Sr co-doped nanoscale hydroxyapatite for osteoinductivity and antibacterial properties

    P. Li, Z. Jia, Q. Wang, P. Tang, M. Wang, K. Wang, J. Fang, C. Zhao, F. Ren, X. Ge and X. Lu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01672K

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