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Iron oxide nanoparticles for targeted imaging of liver tumors with ultralow hepatotoxicity

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Abstract

Even though iron oxide (Fe3O4) nanoparticles are promising materials for magnetic resonance imaging (MRI) contrast agents, their biocompatibility and targeting efficacy still need to be improved. Herein, we modified glycyrrhetinic acid (GA) groups on Fe3O4 nanoparticles (Fe3O4@cGlu-GA) for liver tumor-targeted imaging. To evaluate the biocompatibility of these nanoparticles, we studied their cytotoxicity, hemolysis, and hepatotoxicity. We measured the uptake of Fe3O4@cGlu-GA nanoparticles in normal and liver tumor cells, then we investigated the specificity of Fe3O4@cGlu-GA nanoparticles in mouse models bearing subcutaneous and orthotopic liver tumors. With good biocompatibility and targeting efficacy both in vitro and in vivo, the Fe3O4@cGlu-GA nanoparticles are promising MRI contrast agents with ultralow hepatotoxicity and show great improvement on existing Fe3O4-based nanoparticles.

Graphical abstract: Iron oxide nanoparticles for targeted imaging of liver tumors with ultralow hepatotoxicity

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Publication details

The article was received on 24 Jun 2018, accepted on 03 Sep 2018 and first published on 06 Sep 2018


Article type: Paper
DOI: 10.1039/C8TB01657G
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Iron oxide nanoparticles for targeted imaging of liver tumors with ultralow hepatotoxicity

    J. Li, R. Cha, Y. Zhang, H. Guo, K. Long, P. Gao, X. Wang, F. Zhou and X. Jiang, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB01657G

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