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Biological effects of apatite nanoparticle-constructed ceramic surfaces in regulating behaviours of mesenchymal stem cells

Abstract

Although calcium phosphate (CaP) ceramics have been defined as bioactive materials originally because a biologically active hydroxycarbonate apatite (HCA) layer can form on their surfaces, the biological effects of the grown HCA layers are far from understanding. In particular, it is unclear whether the grown HCA nanotopography can mediate the osteogenic commitment of mesenchymal stem cells (MSCs). In this paper, a systematic study is performed to investigate the formation and biological effects of the HCA nanotopography on the CaP ceramic surfaces. Experiments demonstrate that the hydroxyapatite phase-contained CaP ceramics are fond of growing the HCA nanoparticle-constructed nanotopography, which can mediate bone marrow MSCs to condensate and spontaneous differentiate towards the osteogenic lineage, and the biological evolution of the MSCs adhered on such nanotopography is similar with intramembranous ossification. Our finding provides support for the applications of the wurtzite phase-contained CaP ceramics in regenerative medicine of hard tissues.

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Publication details

The article was received on 21 Jun 2018, accepted on 06 Aug 2018 and first published on 09 Aug 2018


Article type: Paper
DOI: 10.1039/C8TB01638K
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Biological effects of apatite nanoparticle-constructed ceramic surfaces in regulating behaviours of mesenchymal stem cells

    C. Zhou, Y. Jiang, Z. Sun, Y. Li, B. Guo and Y. Hong, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01638K

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