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Issue 38, 2018
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Nanoparticle–proteome in vitro and in vivo

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Abstract

The protein corona is a concept central to a range of disciplines exploiting the bio–nano interface. As the literature continues to expand in this field, it is essential to condense and contextualize the in vitro and in vivo proteome databases accumulated over the past decade: a goal which this review intends to achieve for the benefit of nanomedicine and nanobiotechnology. The parameters used for our review are the physicochemical characteristics of the nanoparticles, their surface ligands, the biological matrix from which a corona was formed, methods employed, plus the top-ten enriched corona proteins. In addition, the protein coronal networks and their implications in vivo are highlighted for selected studies.

Graphical abstract: Nanoparticle–proteome in vitro and in vivo

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Article information


Submitted
21 Jun 2018
Accepted
30 Jul 2018
First published
30 Jul 2018

J. Mater. Chem. B, 2018,6, 6026-6041
Article type
Review Article

Nanoparticle–proteome in vitro and in vivo

M. Wang, O. J. R. Gustafsson, E. H. Pilkington, A. Kakinen, I. Javed, A. Faridi, T. P. Davis and P. C. Ke, J. Mater. Chem. B, 2018, 6, 6026
DOI: 10.1039/C8TB01634H

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