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Issue 39, 2018
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Polymersome–hydrogel composites with combined quick and long-term antibacterial activities

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Abstract

We present an antibacterial polymersome–hydrogel composite that combines the advantages of both antimicrobial peptides and antibiotics. The polymersomes are self-assembled from poly(ε-caprolactone)-block-poly(lysine-stat-phenylalanine) [PCL-b-P(Lys-stat-Phe)], exhibiting long-acting intrinsic antibacterial capabilities against both Gram-positive and Gram-negative bacteria. In addition, penicillin is encapsulated into the polymersomes, showing quick and enhanced antibacterial activities. Furthermore, a dynamic hydrogel network is prepared based on the Schiff base linkages between the aldehyde groups of dibenzaldehyde-functionalized PEG (DF-PEG) and the amino groups of chitosan. During this process, the penicillin-loaded polymersomes are grafted into the hydrogel networks by Schiff base linkages to afford polymersome–hydrogel composites, which exhibit two-stage antibacterial behavior: (1) penicillin can be released from the hydrogel networks for quick antibacterial function; (2) the polymersomes and the remaining penicillin can be further released for long-term antibacterial effects. Overall, this polymersome–hydrogel composite represents a new type of injectable antibacterial biomaterial for quick and long-acting antibacterial applications.

Graphical abstract: Polymersome–hydrogel composites with combined quick and long-term antibacterial activities

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Publication details

The article was received on 18 Jun 2018, accepted on 30 Aug 2018 and first published on 30 Aug 2018


Article type: Paper
DOI: 10.1039/C8TB01608A
Citation: J. Mater. Chem. B, 2018,6, 6311-6321
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    Polymersome–hydrogel composites with combined quick and long-term antibacterial activities

    Y. Hong, Y. Xi, J. Zhang, D. Wang, H. Zhang, N. Yan, S. He and J. Du, J. Mater. Chem. B, 2018, 6, 6311
    DOI: 10.1039/C8TB01608A

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