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Issue 44, 2018
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Enhancing anti-thrombogenicity of biodegradable polyurethanes through drug molecule incorporation

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Abstract

Sufficient and sustained anti-thrombogenicity is essential for blood-contacting materials because blood coagulation and thrombosis caused by platelet adhesion and activation on material surfaces may lead to functional failure and even fatal outcomes. Covalently conjugating anti-thrombogenic moieties into a polymer, instead of surface modification or blending, can maintain the anti-thrombogenicity of the polymer at a high level over time. In this study, a series of randomly crosslinked, elastic, biodegradable polyurethanes (PU-DPA) were synthesized through a one-pot and one-step method from polycaprolactone (PCL) diol, hexamethylene diisocyanate (HDI) and an anti-thrombogenic drug, dipyridamole (DPA). The mechanical properties, hydrophilicity, in vitro degradation, and anti-thrombogenicity of the resultant PU-DPA polymers could be tuned by altering the incorporated DPA amount. The surface and bulk hydrophilicity of the polyurethanes decreased with increasing hydrophobic DPA amounts. All PU-DPA polymers exhibited strong mechanical properties and good elasticity. The degradation rates of PU-DPAs decreased with increasing DPA content in both PBS and lipase/PBS solutions. Covalently incorporating DPA into the polyurethane significantly reduced the platelet deposition compared to that of the polyurethane without DPA, and the polyurethane remained anti-thrombogenicity after degradation. The PU-DPA films also supported the growth of human umbilical vein endothelial cells. The attractive mechanical properties, blood compatibility, and cell compatibility of this anti-thrombogenic biodegradable polyurethane indicate that it has a great potential to be utilized for blood-contacting devices and cardiovascular tissue repair and regeneration.

Graphical abstract: Enhancing anti-thrombogenicity of biodegradable polyurethanes through drug molecule incorporation

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Publication details

The article was received on 16 Jun 2018, accepted on 07 Aug 2018 and first published on 07 Aug 2018


Article type: Paper
DOI: 10.1039/C8TB01582A
Citation: J. Mater. Chem. B, 2018,6, 7288-7297
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    Enhancing anti-thrombogenicity of biodegradable polyurethanes through drug molecule incorporation

    C. Xu, A. E. Kuriakose, D. Truong, P. Punnakitikashem, K. T. Nguyen and Y. Hong, J. Mater. Chem. B, 2018, 6, 7288
    DOI: 10.1039/C8TB01582A

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