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Catechol/Polyethyleneimine Conversion Coating with Enhanced Corrosion Protection of Magnesium Alloys: Potential Applications for Vascular Implant

Abstract

Magnesium (Mg) alloys are promising biodegradable materials but challenges remains in its rapid degradation, especially in the potential use of Mg alloys as vascular stents. Surface modification technique is the most straightforward way to address both desired biocompatibility and inhibit corrosion of Mg alloys. In this work, inspired by the functional moieties (catechols) of mussel adhesive proteins, a mimetic approach to construct organic protective conversion coating on magnesium-zinc-manganese (MgZnMn) alloy is sufficiently investigated. Based on the cross-linking of CA (catechol) and PEI (polyethyleneimine), a CA/PEI conversion coating is developed on MgZnMn alloy. The CA/PEI conversion coating showed enhanced corrosion resistance due to the strong binding and aggregation of units. Moreover, such coating could also provide enough primary amine groups, catechols and quimones, which can be used to immobilize further molecules. Heparin was further grafted onto the CA/PEI, endowing the conversion coating with desired functionality. Vascular cell behavior on such coating is also studied. The improved hemocompatibility, favorable anti-inflammatory ability, suppressed smooth muscle cell proliferation and enhanced endothelialization indicate the potential of such organic conversion coating on MgZnMn alloys as vascular implants.

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Publication details

The article was received on 15 Jun 2018, accepted on 12 Sep 2018 and first published on 13 Sep 2018


Article type: Paper
DOI: 10.1039/C8TB01574K
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Catechol/Polyethyleneimine Conversion Coating with Enhanced Corrosion Protection of Magnesium Alloys: Potential Applications for Vascular Implant

    H. Zhang, L. Xie, X. Shen, T. Shang, R. Luo, X. Li, T. You, J. Wang, N. Huang and Y. Wang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01574K

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