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Issue 42, 2018

Poly(ester amide)-based hybrid hydrogels for efficient transdermal insulin delivery

Author affiliations

Abstract

Transdermal drug delivery is an attractive, non-invasive treatment. It can avoid first-pass hepatic metabolism and provides the possibility of self-administration. Hydrogels are promising biomaterials due to their important qualities such as biocompatibility and biodegradability. Recently, there has been tremendous growth in the area of hydrogels for transdermal drug delivery. In this work, a new kind of arginine-based poly(ester amide) (Arg-PEA) and polyethylene glycol diacrylamide (PEG-DA) hybrid hydrogel was developed for transdermal drug delivery. The hydrogels not only possess excellent swelling capacity, but also have good mechanical properties, which were then evaluated as drug delivery agents using insulin as a model system. Cytotoxicity testing and in vivo skin irritation tests demonstrated that the hydrogels were biocompatible. Finally, the results indicated that the prepared hydrogels could not only perform transdermal drug delivery, but also might regulate blood glucose levels in a mouse model with streptozotocin-induced diabetes.

Graphical abstract: Poly(ester amide)-based hybrid hydrogels for efficient transdermal insulin delivery

Article information


Submitted
05 Jun 2018
Accepted
11 Sep 2018
First published
14 Sep 2018

J. Mater. Chem. B, 2018,6, 6723-6730
Article type
Paper

Poly(ester amide)-based hybrid hydrogels for efficient transdermal insulin delivery

S. Zhang, P. Xin, Q. Ou, G. Hollett, Z. Gu and J. Wu, J. Mater. Chem. B, 2018, 6, 6723 DOI: 10.1039/C8TB01466C

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