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Poly (ester amides) based hybrid hydrogel for efficient transdermal insulin delivery

Abstract

Transdermal drug delivery is an attractive, non-invasive treatment. It can avoid first-pass hepatic metabolism and provides the possibility of self-administration. Hydrogels are promising biomaterials due to their important qualities such as biocompatibility and biodegradability. Recently, there has been tremendous growth in the area of hydrogels for transdermal drug delivery. In this work, a new kind of arginine-based poly(ester amide)s (Arg-PEA) and polyethylene glycol diacrylamide (PEG-DA) hybrid hydrogels were developed for transdermal drug delivery. The hydrogels not only possess excellent swelling capacity, but also have good mechanical properties, which were then evaluated as drug delivery agents using insulin as a model system. Cytotoxicity testing and in vivo skin irritation tests demonstrated that the hydrogels were biocompatible. Finally, the results indicated that the prepared hydrogels could not only transdermally deliver drugs, but also regulate blood glucose levels in a mouse model with streptozotocin-induced diabetes.

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Publication details

The article was received on 05 Jun 2018, accepted on 11 Sep 2018 and first published on 14 Sep 2018


Article type: Paper
DOI: 10.1039/C8TB01466C
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Poly (ester amides) based hybrid hydrogel for efficient transdermal insulin delivery

    S. Zhang, P. Xin, Q. Ou, G. Hollett, Z. Gu and J. Wu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01466C

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