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Injectable hydrogels: A new paradigm for osteochondral tissue engineering

Abstract

Osteochondral tissue engineering has become a promising strategy for repairing focal chondral lesions and early osteoarthritis (OA), which accounts for progressive joint pain and disability in millions of people worldwide. Towards improving osteochondral tissue repair, injectable hydrogels have emerged as a promising matrix due to their wider range of properties such as high water content and porous framework, similarity to the natural extracellular matrix (ECM), the ability to encapsulate cells within the matrix, ability to provide biological cues for cellular differentiation, minimally invasive deployment or delivery, and ability to repair geometrically complex irregular defects. In this review, we have provided an overview of innovative approaches to engineer injectable hydrogels towards improved osteochondral tissue repair. Herein, we have focused on understanding the biology of osteochondral tissue and osteoarthritis along with the need of injectable hydrogels in osteochondral tissue engineering. Furthermore, we have discussed in detail about different biomaterials (natural and synthetic) and various advanced fabrication methods being employed for development of injectable hydrogels in osteochondral repair. In addition, in vitro and in vivo applications of developed injectable hydrogels for osteochondral tissue engineering have also been reviewed. Finally, conclusion and future perspectives of using injectable hydrogels in osteochondral tissue engineering are discussed.

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Publication details

The article was received on 31 May 2018, accepted on 02 Aug 2018 and first published on 02 Aug 2018


Article type: Review Article
DOI: 10.1039/C8TB01430B
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Injectable hydrogels: A new paradigm for osteochondral tissue engineering

    Y. P. Singh, J. C. M, N. Bhardwaj and B. B. Mandal, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01430B

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