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Intrinsically ferromagnetic Fe-doped TiO2 coatings on titanium for accelerating osteoblast response in vitro

Abstract

Microenvironment can regulate osteoblast behavior during the integration process of implant with host bone. Intrinsically magnetic field induced by Fe3+ doped TiO2 coating was applied herein to enhance the cytocompatibility of Ti. Porous TiO2 incorporated with different amounts of Fe (2.27-11.07 Wt%) was directly prepared on Ti by micro-arc oxidation. The microstructure, roughness, wettability, ion releasing and magnetic property of TiO2 coatings were investigated. Cell behaviors, including adhesion, proliferation, differentiation, collagen secretion and extracellular matrix mineralization on coating surfaces were evaluated. The obtained results show that the incorporation of Fe3+ almost did not alter the phase component, topography, roughness and wettability of coatings, and with the increased dose of Fe3+, trace amounts of Fe3+ were released into mediums, while Ca2+ accumulation concentration slightly decreased. Fe-doped TiO2 displayed weakly ferromagnetic property, and its saturation magnetization value increased initially and then decreased with the increased dose of Fe. Compared with the undoped, proliferation, expression of osteogenesis-related genes, collagen secretion and extracellular matrix mineralization of osteoblasts were enhanced on the Fe doped ones, especially for that with 4.25 Wt% Fe. By analyzing the structures and properties of different surfaces and their osteoblast responses, it is deduced that the ferromagnetism of Fe doped TiO2 plays a key role in enhancing the osteoblast behaviors. Such result gives a new perspective for the potential application of ferromagnetic coatings in bone repair.

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Publication details

The article was received on 30 May 2018, accepted on 01 Aug 2018 and first published on 06 Aug 2018


Article type: Paper
DOI: 10.1039/C8TB01414K
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Intrinsically ferromagnetic Fe-doped TiO2 coatings on titanium for accelerating osteoblast response in vitro

    K. Li, T. Yan, Y. Xue, L. Guo, L. Zhang and Y. Han, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01414K

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