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Laponite nanoplatform functionalized with histidine modified oligomeric hyaluronic acid as an effective vehicle for anticancer drug methotrexate

Abstract

As a synthetic clay material, laponite (LAP), with the nanodisk structure together with the negative-charged surface, has been used for effective drug encapsulation by virtue of its interlayer space. In this research task, LAP nanodisk was used to encapsulate the antifolic methotrexate (MTX) for the first time, and the MTX-loaded LAP nanodisks (LAP/MTX) showed a high drug loading efficiency of 80.39%. Then, an efficient and reliable tumor-targeting device rested on the synthesizedoligomeric hyaluronic acid-L-histidine (oHA-His) was wrapped onto the MTX-loaded LAP disks (form LAP/MTX/oHA-His nanohybrids). The drug released from the LAP/MTX/oHA-His nanohybrids was pH-dependent and matched the first-order kinetics which describing the diffusion mechanism. In vitro biological evaluation manifested that the MTX-loaded LAP nanocarriers, particularly the LAP/MTX/oHA-His nanohybrids which own the target ability and lysosomal antineoplastic activity can be effectively internalized by MCF-7 cell line, and exhibited a more prominent anticancer cytotoxicity than free MTX. In vivo study with mice indicates that the LAP/MTX/oHA-His nanohybrids demonstrated much higher antitumor efficiency compared to the LAP/MTX nanohybirds and pure MTX. Taken together, the LAP/oHA-His, a CD44 receptor targeting pH-sensitive multifunctional nanohybirds, conferred the MTX with excellent cytocompatibility, dispersion stability, sustained pH responsive release properties, and improved anticancer activity, and may be further developed as a potential active nanoplatform for various anticancer drugs.

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Publication details

The article was received on 15 May 2018, accepted on 09 Jul 2018 and first published on 10 Jul 2018


Article type: Paper
DOI: 10.1039/C8TB01284A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Laponite nanoplatform functionalized with histidine modified oligomeric hyaluronic acid as an effective vehicle for anticancer drug methotrexate

    J. li, Y. Yang, Y. Yu, Q. Li, G. Tan, Y. Wang, W. Liu and W. Pan, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01284A

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