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Issue 41, 2018
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Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing

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Abstract

Here we describe a rapid inkjet formulation method for screening newly-synthesised cationic materials for siRNA delivery into cancer cells. Reduction responsive oligo-β-aminoesters were prepared and evaluated for their ability to condense siRNA into polyplexes through a fast inkjet printing method. A direct relationship between the oligomer structures and charge densities, and the final cell response in terms of uptake rate and transfection efficacy, was found. The oligo-β-aminoesters were well-tolerated by the cancer cells, compared to conventional cationic polymers so far employed in gene delivery, and were as active in silencing of a representative luciferase gene.

Graphical abstract: Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing

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Supplementary files

Article information


Submitted
08 May 2018
Accepted
01 Jun 2018
First published
09 Oct 2018

This article is Open Access

J. Mater. Chem. B, 2018,6, 6550-6558
Article type
Paper

Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing

T. Lovato, V. Taresco, A. Alazzo, C. Sansone, S. Stolnik, C. Alexander and C. Conte, J. Mater. Chem. B, 2018, 6, 6550
DOI: 10.1039/C8TB01215F

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