Jump to main content
Jump to site search


Lipid-coated mesoporous silica microparticles for controlled delivery of β-galactosidase into intestine

Abstract

β-galactosidase has been drawing increasing attentions for the treatement of lactose intolerance, but its delivery has been impeded by the degradation under gastric conditions. We have demonstrated that the coating of mesoporous silica microparticles (diameter ≈ 9 μm, pore size ≈ 25 nm) with dioleylphosphatidylcholine membranes significantly improved the loading capability and protected the enzymes from the loss of functions under simulated gastric conditions. Once the particles are transferred to simulated intestinal conditions, the digestion of phosphatidylcholine with pancreatin led to a release of functional β-galactosidase. The coating of mesoporous silica nanoparticles with 5 nm-thick phospholipid membranes opens up a large potential towards the controlled release of orally administrated drugs or enzymes to the intestines.

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Apr 2018, accepted on 06 Aug 2018 and first published on 07 Aug 2018


Article type: Paper
DOI: 10.1039/C8TB01114A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
  •   Request permissions

    Lipid-coated mesoporous silica microparticles for controlled delivery of β-galactosidase into intestine

    I. Pavel, M. Giradon, S. El Hajj, S. Parant, F. Amadei, S. Kaufmann, M. Tanaka, V. Fierro, A. Celzard, N. Canilho and A. Pasc, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01114A

Search articles by author

Spotlight

Advertisements