Issue 32, 2018
From the journal:

Journal of Materials Chemistry B

Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic†

Siming Yu, ORCID logo ‡c   Kar-Him Luk,‡b   Siu-To Cheung,b   Kevin Wing-Hin Kwok,b   Ka-Hing Wong*b  and  Tianfeng Chen ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Jinan University, Guangzhou 510632, China
E-mail: tchentf@jnu.edu.cn

b Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China
E-mail: kahing.wong@polyu.edu.hk

c Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China

Abstract

Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.

Graphical abstract: Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8TB01084F
Article type
Communication
Submitted
25 Apr 2018
Accepted
10 Jul 2018
First published
12 Jul 2018

J. Mater. Chem. B, 2018,6, 5215-5219

Permissions

Request permissions

Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic

S. Yu, K. Luk, S. Cheung, K. W. Kwok, K. Wong and T. Chen, J. Mater. Chem. B, 2018, 6, 5215 DOI: 10.1039/C8TB01084F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements