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Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles

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Abstract

ZnO nanoparticles (ZnO NPs) have gained more attention in recent years due to their ability to induce the generation of reactive oxygen species (ROS) under light irradiation. Photo-triggered ROS generation by ZnO NPs and the resulting phototoxicity in cells have found use in antibacterial and anticancer applications. This review highlights recent advances in the development of ZnO NPs and hybrid-type functionalized ZnO NPs for photo-triggered antibacterial and anticancer activities. In addition, various chemical modifications including metal doping, metal hybridization, modification with polymers, and sensitization by organic photosensitizers have been further introduced to enhance the photocatalytic efficiency and ROS generation capability of ZnO NPs. The enhanced ROS generation efficiency of modified ZnO NPs consequently increases their antibacterial and anticancer activities. Additionally, we offer some insights into the design and engineering of next-generation ZnO NPs for more effective antibacterial and anticancer applications.

Graphical abstract: Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles

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Publication details

The article was received on 09 Apr 2018, accepted on 05 Jul 2018 and first published on 06 Jul 2018


Article type: Review Article
DOI: 10.1039/C8TB00948A
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles

    P. Sivakumar, M. Lee, Y. Kim and M. S. Shim, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB00948A

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