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Titanium-based implant comprising porous micro-structure assembled with nanoleaves and controllable silicon ion release for enhanced osseointegration

Abstract

Osseointegration is crucial for early fixation as well as long-term implantation success, hence numerous efforts have been made to tune the surface topography or chemical composition of biomedical implants to improve osseointegration. In this work, the various nanostructures including nanoflocs, nanobundles, nanorods or nanoleaves were introduced to the surface of silicon(Si)-incorporated micro-porous structure to form Si-incorporated micro-nano hierarchical structures on titanium(Ti)-based implant. The osseointegration of the implants were systemically assessed in vivo and in vitro. The in vitro evaluations showed that the nano-structures promoted the protein adsorption, thus modulating the early cellular responses including attachment and spreading of osteoblasts and human endothelial cells (HUVECs), and the subsequent cell proliferation and differentiation. Furthermore, compared with the single micro-porous structure, the nanostructures located over the micro-porous structure protected the Si ions from quick release and allowed the long-term sustained Si ions release, which further contributes to the proliferation and differentiation of osteoblasts and the vascular endothelial growth factor (VEGF) secretion as well as tube formation of HUVECs. Collectively, the favorable nano-surface structures, especially nanoleaves structure, and the constant Si ion release together lead to the robust osteogenic and angiogenic activities. More importantly, in vivo Micro-CT evaluation and histological observations further verified that Si-incorporated micro-nano hierarchical implant with nanoleaves structure could efficiently promote new bone formation, thus being attractive candidate as the next generation bone implant material.

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Publication details

The article was received on 16 Mar 2018, accepted on 05 Jul 2018 and first published on 06 Jul 2018


Article type: Paper
DOI: 10.1039/C8TB00713F
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Titanium-based implant comprising porous micro-structure assembled with nanoleaves and controllable silicon ion release for enhanced osseointegration

    X. He, X. Zhang, J. Li, R. hang, X. Huang, L. Qin, X. Yao and B. tang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00713F

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