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Issue 23, 2018

A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift

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Abstract

Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(III) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.

Graphical abstract: A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift

Supplementary files

Article information


Submitted
10 Mar 2018
Accepted
14 May 2018
First published
15 May 2018

J. Mater. Chem. B, 2018,6, 3855-3858
Article type
Communication

A long-lifetime iridium(III) complex for lysosome tracking with high specificity and a large Stokes shift

J. Liu, K. Vellaisamy, G. Li, C. Yang, S. Wong, C. Leung, S. Pu and D. Ma, J. Mater. Chem. B, 2018, 6, 3855 DOI: 10.1039/C8TB00666K

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