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Multifunctional coatings that mimic the endothelium: surface bound active heparin nanoparticles with in-situ generation of nitric oxide from nitrosothiols

Abstract

Multifunctional coatings that mimic endothelium function in terms of nitric oxide generation and membrane-bound active heparin species are prepared via the immobilization of cystamine-modified heparin/ polyethyleneimine (Hep-Cys/PEI) nanoparticles. Fourier transform infrared spectra (FTIR) and X-ray photoelectron spectroscopy (XPS) were conducted to confirm the coating formation. A function of active heparin releasing and nitric oxide (NO) generating is obtained on material surface after the immobilization of Hep-Cys/PEI nanoparticles. Moreover, nanoparticles-immobilized coating is sufficiently flexible to resist the deformation of 316L SS stent without any destruction. With the introduction of heparin, the antithrombin III (AT-III) binding ability was significantly enhanced with prolonged APTT time. Besides, Hep-Cys/PEI nanoparticles immobilized coating surface not only significantly suppressed the platelet adhesion and activation, but also promoted ECs proliferation and inhibited SMCs proliferation. Besides, milder tissue response was observed on NPs immobilized surface. With the synergistic effect of heparin and nitric oxide generating moieties, such multifunctional coatings presented potential for the modification of vascular materials.

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Publication details

The article was received on 04 Mar 2018, accepted on 31 Jul 2018 and first published on 09 Aug 2018


Article type: Paper
DOI: 10.1039/C8TB00596F
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Multifunctional coatings that mimic the endothelium: surface bound active heparin nanoparticles with in-situ generation of nitric oxide from nitrosothiols

    R. Luo, J. Zhang, W. Zhuang, L. Deng, L. Li, H. Yu, J. Wang, N. Huang and Y. Wang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00596F

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