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Issue 23, 2018
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Timely coordinated phototherapy mediated by mesoporous organosilica coated triangular gold nanoprisms

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Abstract

A variety of nanocarriers have been designed to deliver photosensitizers (PSs) and promote the clinical applications of photodynamic therapy (PDT). However, most of them suffer from insufficient loading capability, premature leakage, and/or unstable therapeutic efficacy. Herein, we constructed a novel nanocomposite (TGP@MOS) with a benzene-bridged mesoporous organosilica shell and a triangular gold nanoprism core. The TGP@MOS could load model PS molecules, zinc phthalocyanine (ZnPc), with high loading capacity (11.8 wt%) and minimal premature leakage (only 2.6% after incubation in PBS with 10% FBS for 60 h) via π–π stacking interactions and hydrophobic interactions. We demonstrated that the obtained TGP@MOS–ZnPc could realize timely coordinated photodynamic/photothermal therapy upon single irradiation, and thus stabilize and maximize the therapeutic efficacy of phototherapy both in vitro and in vivo. Other advantages of TGP@MOS-ZnPc include excellent water solubility, stability, hemocompatibility and biocompatibility.

Graphical abstract: Timely coordinated phototherapy mediated by mesoporous organosilica coated triangular gold nanoprisms

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Publication details

The article was received on 27 Feb 2018, accepted on 23 Apr 2018 and first published on 24 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00541A
Citation: J. Mater. Chem. B, 2018,6, 3865-3875

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    Timely coordinated phototherapy mediated by mesoporous organosilica coated triangular gold nanoprisms

    W. Liu, Y. Tian, Y. Zhang, K. Liu, S. Zhao, J. Zhang, Y. Su, Y. Zhao, Y. Tang, J. Sun, W. Tian, L. Song, Z. Teng, S. Wang and G. Lu, J. Mater. Chem. B, 2018, 6, 3865
    DOI: 10.1039/C8TB00541A

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