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Issue 22, 2018
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Approaches to improve the biocompatibility and systemic circulation of inorganic porous nanoparticles

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Abstract

The exploitation of various inorganic nanoparticles as drug carriers and therapeutics is becoming increasingly common. The first issue to be considered with regard to the nanomaterials being utilized in medicine centers on their safety. The functionality of nanocarriers in real-life environments explains the enthusiasm for their use. Several functionalities are typically added onto nanocarriers but the most crucial feature of those carriers intended to be administered intravenously is that they should possess a long residence time in blood circulation. The present review focusses on the mesoporous nanoparticles due to their great promise in nanomedicine and concentrates on their coatings because it is the outmost layer which dictates their first interactions with the surroundings and often determines their biofate.

Graphical abstract: Approaches to improve the biocompatibility and systemic circulation of inorganic porous nanoparticles

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Supplementary files

Article information


Submitted
16 Feb 2018
Accepted
23 Apr 2018
First published
25 Apr 2018

J. Mater. Chem. B, 2018,6, 3632-3649
Article type
Review Article

Approaches to improve the biocompatibility and systemic circulation of inorganic porous nanoparticles

K. Tamarov, S. Näkki, W. Xu and V.-P. Lehto, J. Mater. Chem. B, 2018, 6, 3632 DOI: 10.1039/C8TB00462E

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