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Peptide functionalized magneto-plasmonic nanoparticles obtained by microfluidics for inhibition of β-amyloid aggregation

Abstract

In the present work, we report on the obtention of peptide functionalized magneto-plasmonic nanoparticles synthesized in a simple microfluidic platform. Superparamagnetic nanoparticles and gold nanorods were selected for this study. Magnetic nanoparticles were functionalized with the peptide D1, which can bind selectively to toxic aggregates of the peptide -amyloid associated with the Alzheimer´s disease. Gold nanorods were functionalized with chitosan replacing the surfactant cetyltrimethylammonium bromide to reduce the cytotoxic effect. The selected microfluidic strategy yields structures with plasmonic and magnetic properties in a nanostructure. Cytotoxic assays with SH-SY5Y cells demonstrate that nanoparticles obtained by microfluidics do not affect the cell viability at the studied concentrations. Additionally, these magneto-plasmonic nanoparticles inhibit the fibrils formation demonstrating that the magneto-plasmonic nanoparticles obtained by microfluidics could be applied for a potential treatment and diagnostic of Alzheimer´s disease.

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Publication details

The article was received on 23 Jan 2018, accepted on 05 Jul 2018 and first published on 06 Jul 2018


Article type: Paper
DOI: 10.1039/C8TB00206A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Peptide functionalized magneto-plasmonic nanoparticles obtained by microfluidics for inhibition of β-amyloid aggregation

    N. Hassan, M. Cordero, R. Sierpe, M. Almada, J. Juarez-Onofre, M. A. Valdez, A. Riveros, E. Vargas, A. Abou-Hassan, J. M. Ruso and M. Kogan, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00206A

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