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Issue 14, 2018
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Combined therapies with nanostructured carbon materials: there is room still available at the bottom

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Abstract

The progress of the chemistry of carbon nanotubes (CNT) and graphene derivatives [mainly graphene oxide (GO)] has produced a number of technologically advanced drug delivery systems (DDS) that have been used in the field of nanomedicine, mostly in studies related to oncology. However, such a demanding field of research requires continuous improvements in terms of efficiency, selectivity and versatility. The loading of two, or more, bioactive components on the same nanoparticle offers new possibilities for treating cancer, efficiently addressing issues related both to biodistribution and pharmacokinetics. Nanostructured carbon materials (NCM), with their high surface area, their efficient cellular membrane crossing and their chemical versatility are ideal candidates for easy hetero-decoration and exploitation as advanced DDS. This review describes the achievements obtained in this area focusing on those studies in which two or more active components were loaded onto the DDS.

Graphical abstract: Combined therapies with nanostructured carbon materials: there is room still available at the bottom

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Article information


Submitted
15 Jan 2018
Accepted
19 Feb 2018
First published
19 Feb 2018

J. Mater. Chem. B, 2018,6, 2022-2035
Article type
Review Article

Combined therapies with nanostructured carbon materials: there is room still available at the bottom

G. Biagiotti, S. Fedeli, G. Tuci, L. Luconi, G. Giambastiani, A. Brandi, F. Pisaneschi, S. Cicchi and P. Paoli, J. Mater. Chem. B, 2018, 6, 2022 DOI: 10.1039/C8TB00121A

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