Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 10, 2018
Previous Article Next Article

Oral administration of highly bright Cr3+ doped ZnGa2O4 nanocrystals for in vivo targeted imaging of orthotopic breast cancer

Author affiliations

Abstract

Near-infrared (NIR) long lasting persistent luminescence nanoparticles (PLNPs) have attracted considerable attention in the area of in vivo bioimaging, due to their background-free luminescence characteristics and deep tissue penetration. However, the low fluorescence quantum yield and short afterglow of the currently available PLNPs limit their applications. Here, water-soluble Cr3+-doped ZnGa2O4 PLNPs with the highest quantum yield (η = 20%) ever reported, bright NIR emission, and excellent colloidal stability were successfully prepared by a one-step hydrothermal method. The afterglow of the resultant nanocrystals lasted for more than 5 days and could be repeatedly reactivated by the light (λ = 657 nm) of a portable light emitting diode lamp after decay. These nanocrystals were functionalized with α,ω-dicarboxyl-terminated poly(ethylene glycol) and poly(acrylic acid) to improve their stability and biocompatibility, so that they could be conjugated with a c(RGDyK) peptide and labeled with 99mTc for targeted imaging of orthotopic breast cancer by afterglow luminescence imaging and single-photon emission computed tomography imaging. Our NIR-PLNP probes can effectively avoid tissue auto-fluorescence and the light scattering caused by continuous excitation during the diagnosis of cancer.

Graphical abstract: Oral administration of highly bright Cr3+ doped ZnGa2O4 nanocrystals for in vivo targeted imaging of orthotopic breast cancer

Back to tab navigation

Supplementary files

Article information


Submitted
06 Dec 2017
Accepted
05 Feb 2018
First published
05 Feb 2018

J. Mater. Chem. B, 2018,6, 1508-1518
Article type
Paper

Oral administration of highly bright Cr3+ doped ZnGa2O4 nanocrystals for in vivo targeted imaging of orthotopic breast cancer

H. Liu, F. Ren, H. Zhang, Y. Han, H. Qin, J. Zeng, Y. Wang, Q. Sun, Z. Li and M. Gao, J. Mater. Chem. B, 2018, 6, 1508
DOI: 10.1039/C7TB03148C

Social activity

Search articles by author

Spotlight

Advertisements