Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 8, 2018
Previous Article Next Article

Switching off the interactions between graphene oxide and doxorubicin using vitamin C: combining simplicity and efficiency in drug delivery

Author affiliations

Abstract

Well-controlled, low-toxicity and highly efficient delivery systems for anticancer drugs are a key challenge for the development of a new class of nanocarrier systems for cancer chemotherapy. Graphene oxide (GO) has been developed to be a nanocarrier of anti-cancer drugs due to its large surface area and biocompatibility; however, understanding of the interface chemistry is very limited. In this work, we report efficient loading and controlled release of doxorubicin (DOX) using the tunable surface of GO. A deep understanding of the surface chemistry between GO and DOX is achieved using spectroscopies and atomic force microscopy. Hydrogen bonding and π–π stacking are confirmed to be the non-covalent interactions between the drugs and the carriers. As a result, improvement of DOX delivery from the GO surface can be achieved using vitamin C.

Graphical abstract: Switching off the interactions between graphene oxide and doxorubicin using vitamin C: combining simplicity and efficiency in drug delivery

Back to tab navigation

Supplementary files

Article information


Submitted
26 Nov 2017
Accepted
20 Jan 2018
First published
22 Jan 2018

J. Mater. Chem. B, 2018,6, 1251-1259
Article type
Paper

Switching off the interactions between graphene oxide and doxorubicin using vitamin C: combining simplicity and efficiency in drug delivery

Z. Liu, J. Liu, T. Wang, Q. Li, P. S. Francis, C. J. Barrow, W. Duan and W. Yang, J. Mater. Chem. B, 2018, 6, 1251
DOI: 10.1039/C7TB03063K

Social activity

Search articles by author

Spotlight

Advertisements