Issue 3, 2019

pH-Induced reorientation of cytochrome c on silica nanoparticles

Abstract

The orientation of cytochrome c molecules at the surface of silica nanoparticles was studied in a wide pH range by combining small-angle neutron scattering, adsorption measurements, and molecular dynamics simulations. The results indicate a reorientation of the ellipsoidal protein from head-on to side-on as the pH is increased. This is attributed to changes in the surface charge distribution of both the protein and the nanoparticles.

Graphical abstract: pH-Induced reorientation of cytochrome c on silica nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
18 Sep 2018
Accepted
16 Nov 2018
First published
16 Nov 2018

Soft Matter, 2019,15, 350-354

Author version available

pH-Induced reorientation of cytochrome c on silica nanoparticles

J. Meissner, Y. Wu, J. Jestin, W. A. Shelton, G. H. Findenegg and B. Bharti, Soft Matter, 2019, 15, 350 DOI: 10.1039/C8SM01909F

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