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Supramolecular hydrogel prepared from thymine-containing artificial nucleolipid: study of assembly and lyotropic mesophases

Abstract

An artificial nucleolipid containing thymine, a triazole-ring, and phosphotidylcholine moieties (TTPC) was prepared through copper catalyzed azide alkyne cycloaddition (CuAAC) under aqueous conditions. The resulting TTPC molecules assembled in-situ into a fibrous aggregation. The study of the TTPC fiber assembly using XRD and NMR revealed that the formation of the fibers was driven by the unique combination of the lipid and nucleobase moieties in the structure of TTPC. At a critical TTPC concentration, entanglement of the fibers resulted in a supramolecular hydrogel. Investigation of the lyotropic mesophases in the TTPC supramolecular hydrogel showed the presence of multiple phases including two liquid crystal phases (i.e., nematic and lamellar), which have a certain degree of structural order and are promising templates for constructing functional biomaterials.

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Publication details

The article was received on 06 Jul 2018, accepted on 02 Aug 2018 and first published on 02 Aug 2018


Article type: Paper
DOI: 10.1039/C8SM01383G
Citation: Soft Matter, 2018, Accepted Manuscript
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    Supramolecular hydrogel prepared from thymine-containing artificial nucleolipid: study of assembly and lyotropic mesophases

    D. Zhang, Q. Liu, R. VISVANATHAN, M. Tuchband, G. Sheetah, B. Fairbanks, N. A. Clark, I. Smalyukh and C. N. Bowman, Soft Matter, 2018, Accepted Manuscript , DOI: 10.1039/C8SM01383G

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