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Issue 34, 2018
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A supramolecular hydrogel prepared from a thymine-containing artificial nucleolipid: study of assembly and lyotropic mesophases

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Abstract

An artificial nucleolipid containing thymine, a triazole-ring, and phosphatidylcholine (TTPC) moieties was prepared by copper catalyzed azide alkyne cycloaddition (CuAAC) under aqueous conditions. The resulting TTPC molecules assembled in situ into a fibrous aggregation. The study of the TTPC fiber assembly using XRD and NMR spectroscopy revealed that the formation of fibers was driven by the unique combination of the lipid and nucleobase moieties in the structure of TTPC. At a critical TTPC concentration, entanglement of the fibers resulted in the formation of a supramolecular hydrogel. Investigation of the lyotropic mesophases in the TTPC supramolecular hydrogel showed the presence of multiple phases including two liquid crystal phases (i.e., nematic and lamellar), which have a certain degree of structural order and are promising templates for constructing functional biomaterials.

Graphical abstract: A supramolecular hydrogel prepared from a thymine-containing artificial nucleolipid: study of assembly and lyotropic mesophases

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Publication details

The article was received on 06 Jul 2018, accepted on 02 Aug 2018 and first published on 02 Aug 2018


Article type: Paper
DOI: 10.1039/C8SM01383G
Citation: Soft Matter, 2018,14, 7045-7051
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    A supramolecular hydrogel prepared from a thymine-containing artificial nucleolipid: study of assembly and lyotropic mesophases

    D. Zhang, Q. Liu, R. Visvanathan, M. R. Tuchband, G. H. Sheetah, B. D. Fairbanks, N. A. Clark, I. I. Smalyukh and C. N. Bowman, Soft Matter, 2018, 14, 7045
    DOI: 10.1039/C8SM01383G

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