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Issue 40, 2018
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Laser trapping/confocal Raman spectroscopic characterization of PLGA-PEG nanoparticles

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Abstract

We have immobilized poly(ethylene glycol) (PEG) on the surfaces of poly(lactic-co-glycolic acid) (PLGA) nanoparticles by two different chemical methods, i.e., SOCl2 halogenate-alcoholysis and DCC dehydration. The immobilized PLGA nanoparticles were characterized by DLS, 1H NMR, FT-IR and laser trapping/confocal Raman spectroscopic techniques. As a result, especially the Raman spectra which were measured after optically trapping ca. 10 individual nanoparticles in solution indicated that the PLGA nanoparticles were successfully immobilized with the PEG by the chemical methods.

Graphical abstract: Laser trapping/confocal Raman spectroscopic characterization of PLGA-PEG nanoparticles

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Publication details

The article was received on 04 Jul 2018, accepted on 12 Sep 2018 and first published on 13 Sep 2018


Article type: Communication
DOI: 10.1039/C8SM01364K
Citation: Soft Matter, 2018,14, 8090-8094
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    Laser trapping/confocal Raman spectroscopic characterization of PLGA-PEG nanoparticles

    J. Yang, R. Zhang, D. Liu, X. Zhou, T. Shoji, Y. Tsuboi and H. Yan, Soft Matter, 2018, 14, 8090
    DOI: 10.1039/C8SM01364K

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