Issue 16, 2018

Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures

Abstract

We investigated the effects of lipid geometry on vesicle division using coarse grained molecular dynamics simulations. When the vesicle is composed of zero and negative spontaneous curvature lipids (ZSLs and NSLs), the difference in their molecular spontaneous curvatures destabilizes the neck of the limiting shape vesicle. In the vesicle division pathway, the neck developed into the stalk intermediates. The stalk was broken when the NSLs were expelled from the stalk. Free energy analysis shows that the coupling between the lipid geometry and the Gaussian rigidity is responsible for the observed vesicle division.

Graphical abstract: Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures

Supplementary files

Article information

Article type
Paper
Submitted
07 Nov 2017
Accepted
16 Feb 2018
First published
19 Feb 2018

Soft Matter, 2018,14, 3018-3027

Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures

N. Urakami, T. Jimbo, Y. Sakuma and M. Imai, Soft Matter, 2018, 14, 3018 DOI: 10.1039/C7SM02188G

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