Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 16, 2018
Previous Article Next Article

Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures

Author affiliations

Abstract

We investigated the effects of lipid geometry on vesicle division using coarse grained molecular dynamics simulations. When the vesicle is composed of zero and negative spontaneous curvature lipids (ZSLs and NSLs), the difference in their molecular spontaneous curvatures destabilizes the neck of the limiting shape vesicle. In the vesicle division pathway, the neck developed into the stalk intermediates. The stalk was broken when the NSLs were expelled from the stalk. Free energy analysis shows that the coupling between the lipid geometry and the Gaussian rigidity is responsible for the observed vesicle division.

Graphical abstract: Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures

Back to tab navigation

Supplementary files

Article information


Submitted
07 Nov 2017
Accepted
16 Feb 2018
First published
19 Feb 2018

Soft Matter, 2018,14, 3018-3027
Article type
Paper

Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures

N. Urakami, T. Jimbo, Y. Sakuma and M. Imai, Soft Matter, 2018, 14, 3018
DOI: 10.1039/C7SM02188G

Social activity

Search articles by author

Spotlight

Advertisements