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Issue 48, 2018
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Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling

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Abstract

An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF3 pyridines, through the regioselective, sequential formation of two C–C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules.

Graphical abstract: Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling

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Publication details

The article was received on 06 Aug 2018, accepted on 02 Oct 2018 and first published on 02 Oct 2018


Article type: Edge Article
DOI: 10.1039/C8SC03493A
Citation: Chem. Sci., 2018,9, 9012-9017
  • Open access: Creative Commons BY license
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    Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling

    D. Chen, L. Xu, T. Long, S. Zhu, J. Yang and L. Chu, Chem. Sci., 2018, 9, 9012
    DOI: 10.1039/C8SC03493A

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