Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling†
An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF3 pyridines, through the regioselective, sequential formation of two C–C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules.
- This article is part of the themed collection: 2019 International Open Access Week Collection