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Issue 48, 2018
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Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling

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Abstract

An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF3 pyridines, through the regioselective, sequential formation of two C–C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules.

Graphical abstract: Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling

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Supplementary files

Article information


Submitted
06 Aug 2018
Accepted
02 Oct 2018
First published
02 Oct 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 9012-9017
Article type
Edge Article

Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling

D. Chen, L. Xu, T. Long, S. Zhu, J. Yang and L. Chu, Chem. Sci., 2018, 9, 9012
DOI: 10.1039/C8SC03493A

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