Jump to main content
Jump to site search

Issue 1, 2019
Previous Article Next Article

Wetting the lock and key enthalpically favours polyelectrolyte binding

Author affiliations

Abstract

By using a combination of readily accessible experimental and computational experiments in water, we explored the factors governing the association between polyanionic dyn[4]arene and a series of α,ω-alkyldiammonium ions of increasing chain length. We found that the lock-and-key concept based on the best match between the apolar and polar regions of the molecular partners failed to explain the observed selectivities. Instead, the dissection of the energetic and structural contributions demonstrated that the binding events were actually guided by two crucial solvent-related phenomena as the chain length of the guest increases: the expected decrease of the enthalpic cost of guest desolvation and the unexpected increase of the favourable enthalpy of complex solvation. By bringing to light the decisive enthalpic impact of complex solvation during the binding of polyelectrolytes by inclusion, this study may provide a missing piece to a puzzle that one day could display the global picture of molecular recognition in water.

Graphical abstract: Wetting the lock and key enthalpically favours polyelectrolyte binding

Back to tab navigation

Supplementary files

Article information


Submitted
05 Jul 2018
Accepted
06 Oct 2018
First published
08 Oct 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2019,10, 277-283
Article type
Edge Article

Wetting the lock and key enthalpically favours polyelectrolyte binding

E. Jeamet, J. Septavaux, A. Héloin, M. Donnier-Maréchal, M. Dumartin, B. Ourri, P. Mandal, I. Huc, E. Bignon, E. Dumont, C. Morell, J. Francoia, F. Perret, L. Vial and J. Leclaire, Chem. Sci., 2019, 10, 277
DOI: 10.1039/C8SC02966K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements