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A one-step method for covalent bond immobilization of biomolecules on silica operated in aqueous solution

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Abstract

A simple, one-step method for covalent bond immobilization of biomolecules on silica operated in water is described. In the approach, an NHS-ester linked methallylsilane is utilized as a bifunctional linker to couple the biomolecule to the silica surface. Weak organic acid such as acetic acid activates the silica surface enough to react with bifunctional linker without destroying activity of biomolecule.

Graphical abstract: A one-step method for covalent bond immobilization of biomolecules on silica operated in aqueous solution

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Publication details

The article was received on 11 Jun 2018, accepted on 23 Aug 2018 and first published on 24 Aug 2018


Article type: Edge Article
DOI: 10.1039/C8SC02565G
Citation: Chem. Sci., 2018, Advance Article
  • Open access: Creative Commons BY license
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    A one-step method for covalent bond immobilization of biomolecules on silica operated in aqueous solution

    Y. Sim, H. Jung, S. H. Kim, J. Park, W. Park and C. Jun, Chem. Sci., 2018, Advance Article , DOI: 10.1039/C8SC02565G

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