Issue 41, 2018
From the journal:

Chemical Science

A one-step method for covalent bond immobilization of biomolecules on silica operated in aqueous solution†

Yong-Kyun Sim,a   Heetae Jung,a   Su Hyun Kim,a   Jung-Woo Park, ORCID logo b   Woo-Jin Parka  and  Chul-Ho Jun ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
E-mail: junch@yonsei.ac.kr

b Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon 34141, Republic of Korea

Abstract

A simple, one-step method for covalent bond immobilization of biomolecules on silica operated in water is described. In the approach, an NHS-ester linked methallylsilane is utilized as a bifunctional linker to couple the biomolecule to the silica surface. Weak organic acid such as acetic acid activates the silica surface enough to react with bifunctional linker without destroying activity of biomolecule.

Graphical abstract: A one-step method for covalent bond immobilization of biomolecules on silica operated in aqueous solution

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Article information

DOI
https://doi.org/10.1039/C8SC02565G
Article type
Edge Article
Submitted
11 Jun 2018
Accepted
23 Aug 2018
First published
24 Aug 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2018,9, 7981-7985

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A one-step method for covalent bond immobilization of biomolecules on silica operated in aqueous solution

Y. Sim, H. Jung, S. H. Kim, J. Park, W. Park and C. Jun, Chem. Sci., 2018, 9, 7981 DOI: 10.1039/C8SC02565G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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