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Issue 48, 2018
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Molybdenum sulfide–reduced graphene oxide p–n heterojunction nanosheets with anchored oxygen generating manganese dioxide nanoparticles for enhanced photodynamic therapy

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Abstract

In an unprecedented approach, p–n heterojunction nanosheets comprising ∼5 nm thick p-type MoS2 nanoplates integrated onto n-type nitrogen doped reduced graphene oxide (n-rGO) have been employed for photodynamic therapy (PDT). When near infrared (NIR) light with 980 nm wavelength was irradiated on this nanocomposite, effective electron–hole separation was obtained across the heterojunction. The nanosheets were modified with lipoic acid functionalized poly(ethylene glycol) to provide better biocompatibility and colloidal stability in physiological solution. The surface decorated 3–5 nm MnO2 nanoparticles (NPs) triggered the disproportionation of intracellular H2O2 which improved generation of reactive oxygen species (ROS) for enhanced PDT cancer therapy, studied in vitro. The role of N-doping in rGO and the effect of immobilization of MnO2 NPs were systematically investigated by control experiments. Our smartly designed p-MoS2/n-rGO–MnO2–PEG nanosheets outperform conventional PDT agents by overcoming limitations such as low absorption band, unfavourable bioavailability and limitations in tissue oxygenation.

Graphical abstract: Molybdenum sulfide–reduced graphene oxide p–n heterojunction nanosheets with anchored oxygen generating manganese dioxide nanoparticles for enhanced photodynamic therapy

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Publication details

The article was received on 07 Jun 2018, accepted on 29 Sep 2018 and first published on 01 Oct 2018


Article type: Edge Article
DOI: 10.1039/C8SC02508H
Citation: Chem. Sci., 2018,9, 8982-8989
  • Open access: Creative Commons BY-NC license
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    Molybdenum sulfide–reduced graphene oxide p–n heterojunction nanosheets with anchored oxygen generating manganese dioxide nanoparticles for enhanced photodynamic therapy

    S. Kapri and S. Bhattacharyya, Chem. Sci., 2018, 9, 8982
    DOI: 10.1039/C8SC02508H

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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      [Original citation] - Published by The Royal Society of Chemistry.

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