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A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy

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Abstract

Development of tumor microenvironment responsive and modulating theranostic nano-systems is of great importance for specific and efficient cancer therapy. Herein, we report a redox-sensitive nanoagent combining manganese dioxide (MnO2) and gold nanoshell coated silicon nanoparticles for synergistic chemo-photothermal therapy of hypoxia solid tumors. In highly reducing tumor tissues, the outer MnO2 nanosheet with the loaded drug would be dissociated by intracellular glutathione (GSH), resulting in on-demand drug release, as well as generating Mn2+ ions which provided high contrast magnetic resonance imaging (MRI), and fluorescence imaging (FI) in vitro and in vivo. While upon near-infrared (NIR) light irradiation, the gold nanoshell modulated the hypoxic tumor microenvironment via increasing blood flow, achieving enhanced photothermal therapy (PTT) and chemotherapy. After tail vein injection into tumor-bearing mice and monitoring in real time, the intelligent redox-activated nanoagent exhibited high tumor accumulation and powerful synergistic chemo-photothermal therapy efficiency. The proposed work developed a noninvasive strategy to modulate the tumor microenvironment and enhance the anticancer therapeutic effect. We believe that this single nano-platform exhibits promising potential as a comprehensive theranostic agent to enhance the efficacies of synergistic cancer therapy.

Graphical abstract: A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy

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Publication details

The article was received on 04 Jun 2018, accepted on 30 Jun 2018 and first published on 02 Jul 2018


Article type: Edge Article
DOI: 10.1039/C8SC02446D
Citation: Chem. Sci., 2018, Advance Article
  • Open access: Creative Commons BY-NC license
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    A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy

    T. Zhang, C. Xu, W. Zhao, Y. Gu, X. Li, J. Xu and H. Chen, Chem. Sci., 2018, Advance Article , DOI: 10.1039/C8SC02446D

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