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Issue 31, 2018
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Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes

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Abstract

A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an in situ formed copper hydride. A variety of allyl electrophiles could be utilized yielding a diverse range of trisubstituted cyclopropanes. Finally a preliminary enantioselective variant could be established employing a recently described P-stereogenic xantphos derivative as ligand.

Graphical abstract: Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes

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Supplementary files

Article information


Submitted
10 May 2018
Accepted
29 Jun 2018
First published
02 Jul 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 6503-6508
Article type
Edge Article

Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes

H. Sommer and I. Marek, Chem. Sci., 2018, 9, 6503
DOI: 10.1039/C8SC02085J

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